Next Article in Journal
Mucolipidoses Overview: Past, Present, and Future
Previous Article in Journal
Antimicrobial Peptides with Enhanced Salt Resistance and Antiendotoxin Properties
Open AccessArticle

Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells

Department of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 22381 Lund, Sweden
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
CEINGE Biotecnologie Avanzate, Via G Salvatore, 80131 Naples, Italy
School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
Institute of Medical Virology, Clinics of the Goethe-University, D-60596 Frankfurt am Main, Germany
IRCCS SDN, Via Emanuele Gianturco, 113, 80143 Naples, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6811;
Received: 27 July 2020 / Revised: 11 September 2020 / Accepted: 15 September 2020 / Published: 16 September 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles. View Full-Text
Keywords: chemoresistance; neuroblastoma; vincristine chemoresistance; neuroblastoma; vincristine
Show Figures

Figure 1

MDPI and ACS Style

Jemaà, M.; Sime, W.; Abassi, Y.; Lasorsa, V.A.; Bonne Køhler, J.; Michaelis, M.; Cinatl, J., Jr.; Capasso, M.; Massoumi, R. Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells. Int. J. Mol. Sci. 2020, 21, 6811.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop