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Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells

1
Department of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 22381 Lund, Sweden
2
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
3
CEINGE Biotecnologie Avanzate, Via G Salvatore, 80131 Naples, Italy
4
School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
5
Institute of Medical Virology, Clinics of the Goethe-University, D-60596 Frankfurt am Main, Germany
6
IRCCS SDN, Via Emanuele Gianturco, 113, 80143 Naples, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6811; https://doi.org/10.3390/ijms21186811
Received: 27 July 2020 / Revised: 11 September 2020 / Accepted: 15 September 2020 / Published: 16 September 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles. View Full-Text
Keywords: chemoresistance; neuroblastoma; vincristine chemoresistance; neuroblastoma; vincristine
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MDPI and ACS Style

Jemaà, M.; Sime, W.; Abassi, Y.; Lasorsa, V.A.; Bonne Køhler, J.; Michaelis, M.; Cinatl, J., Jr.; Capasso, M.; Massoumi, R. Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells. Int. J. Mol. Sci. 2020, 21, 6811.

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